Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma–like and Non–Small Cell Carcinoma–like Subsets
نویسندگان
چکیده
منابع مشابه
Pulmonary Large-Cell Neuroendocrine Carcinoma
Lung neuroendocrine tumors are a heterogeneous sub-type of pulmonary cancers representing approximately 20% of all lung cancers, including small-cell lung cancer (SCLC) and large-cell neuroendocrine carcinoma (LCNEC). The frequency appears to be approximately 3% for LCNEC. Diagnosis of LCNEC requires attention to neuroendocrine features by light microscopy and confirmation by immunohistochemica...
متن کاملTherapeutic strategies and genetic profile comparisons in small cell carcinoma and large cell neuroendocrine carcinoma of the lung using next-generation sequencing
Small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC) of the lung are classified as variants of endocrine carcinoma and subdivided into pure or combined type. Clinical benefit of target therapy has not been established in these tumors. This study aimed to compare genetic and clinicopathological features between SCLC and LCNEC or pure and combined types, and explore the p...
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Lung cancer metastases to the prostate are uncommon, and are usually found incidentally during autopsy. This case report describes a 77-year-old man with a large cell neuroendocrine carcinoma (LCNEC) of the lung and metastases from this primary cancer in the prostate. During the follow-up after the chemotherapy performed for pulmonary LCNEC, pelvic computed tomography revealed a prostatic tumor...
متن کاملHigh survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma.
UNLABELLED In the revised WHO classification of lung cancer, published in 1999, large cell neuroendocrine carcinoma (LCNEC) was employed as a new histological entity. LCNEC is generally considered a high-grade malignant lung cancer, and appropriate treatment remains to be determined. Before its new classification, LCNEC had long been classified into several entities. Advancing the review of pre...
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1. Resident in Dermatology, Department of Dermatology, Curry Cabral Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal 2. Senior Consultant, Department of Dermatology, Curry Cabral Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal 3. Head, Department of Dermatology, Curry Cabral Hospital, Centro Hospitalar de Lisboa Central, Central Lisbon Hospital Center – Lisbon, Po...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2016
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-15-2946